Cancer Treatment with Alternating Electric Fields (TTFields)

Yoram Palti, MD, Ph.D.
Technion – Israel Inst. of Technology & NovoCure Ltd.
Haifa, Israel

-Jueves 19 de Marzo de 2009; a las 16:00 h
-Facultad de Medicina, Biblioteca Central, Sala de Profesores (Sala azul),
Paraguay 2155, 4to. piso (ascensor izquierda).

Hosts: Laboratorio de Sistemas Complejos, Departamento de Computación,
Facultad de Ciencias Exactas y Naturales, UBA. Laboratorio de Metabolismo del
Oxígeno, Hospital de Clínicas, Facultad de Medicina (UBA). Laboratorio de
Fisiologia y Biologia Molecular (LFBM) Fac. de Cs. Exactas (UBA).

Recently, a novel anti-cancer treatment modality, named Tumor Treating Fields
(TTFields) was introduced. TTFields are low intensity, intermediate frequency
alternating electric fields that were shown to disrupt cancer cell
replication in-vitro and to slow tumor progression in animal cancer models
and in patients with recurrent and newly diagnosed glioblastoma brain tumors
as well as NSCLC lung carcinoma (1-3).
This presentation will discuss the mechanisms involved and some of the
clinical results obtained thus far.

1. Alternating electric fields arrest cell proliferation in animal tumor
models and human brain tumors. Proc Natl Acad Sci U S A 2007; 104 (24):
2. Disruption of cancer cell replication by alternating electric fields.
Cancer Res 2004; 64: 3288-95.
3. Chemotherapeutic Treatment Efficacy and Sensitivity are Increased by
Adjuvant Alternating Electric Fields (TTFields). BMC Med Phys 2009; 9 (1): 1.

Y O R A M P A L T I MD, Ph.D. Short Curriculum Vitae
E d u c a t i o n
1957 – 1964 MD, Hebrew University – Hadassah Medical School, Jerusalem,
1962 – 1965 Ph.D. in Physiology & Biophysics, Hebrew University – Hadassah
Medical School, Jerusalem, Israel.
Thesis: “The influence of alternating electromagnetic fields on peripheral

P r o f e s s i o n a l E x p e r i e n c e
1976 – Professor of Physiology & Biophysics, Faculty of Medicine, Technion –
Israel Institute of Technology, Haifa, Israel.
1982 – 1993 Director – The Rappaport Institute for Research in the Medical
Sciences, Technion, Haifa, Israel.
1972 – 1981 Consultant, Francis Bitter National Magnet Lab., M.I.T. (Low
Fields Lab.), Cambridge, Mass., USA.
1969 – 1971 Assoc. Prof. of Physiology, University of Maryland School of
Medicine, Baltimore, Maryland.

Hi Tech

2000 – Founder, NovoCure Ltd., a company dedicated to the development of a
novel technology designed to cure cancer as well as infections by bacteria,
fungus and parasites.
1998 – 1999 Founder, Interspark Ltd., Haifa, Israel. Interspark developed
Blood Pressure measuring equipment, acquired by Philips Electronics of
1993 – Founder, Carmel BioSensors Ltd developed a cell based technology for
biosensors such as continuous blood Glucose monitoring for diabetics