POSTDOCTORAL POSITIONS are now available at the University of Pennsylvania to study the biophysics of microtubule motor proteins and/or microtubule plus end dynamics using single molecule approaches. A Ph.D. in cell biology, biochemistry, biophysics, biological chemistry,
physics, or molecular biology is preferred. The funded position is part of a collaborative project between the laboratories of Dr. Erika Holzbaur and Dr. Yale E. Goldman, in the Dept. of Physiology in the School of Medicine and Pennsylvania Muscle Institute. The research involves the use of single molecule approaches both in vitro and in vivo to examine microtubule motor function and microtubule plus end dynamics in molecular detail.
Please send your curriculum vitae and a list of three references to Erika Holzbaur, Dept. of Physiology, University of Pennsylvania School of Medicine, D400 Richards Building, 3700 Hamilton Walk, Philadelphia , PA 19104-6085. E-mail: holzbaur [arroba] mail.med.upenn.edu or Yale E. Goldman, Pennsylvania Muscle Institute, University of Pennsylvania School of Medicine, D700 Richards Building, 3700 Hamilton Walk, Philadelphia , PA 19104-6083. E-mail: goldmany [arroba] mail.med.upenn.edu The University of Pennsylvania is an Equal Opportunity Employer.
Some Recent References:
Dixit R, Ross JL, Goldman YE, Holzbaur ELF. Differential Regulation of Dynein and Kinesin Motor Proteins by Tau. In Press Science. 2008.
Ross JL, Shuman H, Holzbaur ELF, Goldman YE. Kinesin and Dynein-Dynactin at Intersecting Microtubules: Motor Number Affects Dynein but not Kinesin Function In Press Biophys. J. 2008.
Ross JL, Wallace K, Shuman H, Goldman YE, Holzbaur EL. Processive bidirectional motion of dynein-dynactin complexes in vitro.
Nat Cell Biol. 8:562-70. 2006
Ligon LA, Holzbaur EL. Microtubules tethered at epithelial cell junctions by dynein facilitate efficient junction assembly.
Traffic. 8:808-19. 2007
Caviston JP, Ross JL, Antony SM, Tokito M, Holzbaur EL. Huntingtin facilitates dynein/dynactin-mediated vesicle transport.
Proc Natl Acad Sci 104:10045-50. 2007.
Levy JR, Holzbaur EL. Special delivery: dynamic targeting via cortical capture of microtubules.
Dev Cell. 12:320-2. 2007.
Caviston JP, Holzbaur EL. Microtubule motors at the intersection of trafficking and transport. Trends Cell Biol. 6:530-7. 2006.
Sun, Y, Schroeder, HW III, Beausang, JF, Homma, K, Ikebe, M, Goldman YE. Myosin VI walks “wiggly” on actin with large and variable tilting. Molecular Cell 28:954-64. 2007.
Wang Y, Qin H, Kudaravalli R, Kirillov S, Dempsey GT, Pan D, Cooperman BS, Goldman YE. Single Molecule Structural Dynamics of EF-G·Ribosome Interaction During Translocation Biochemistry, 46:10767-75. 2007.
Toprak, E, Enderlein, J, Syed, S, McKinney , SA. Petschek, RG, Ha, T, Goldman, YE, Selvin. PR. 3-D Orientation and Position Imaging of Myosin V. Proc. Nat. Acad. Sci. 103:6495-6499. 2006
Syed S, Snyder GE, Franzini-Armstrong C, Selvin PR, Goldman YE. Adaptability of Myosin V Studied by Simultaneous Detection of Position and Orientation. EMBO J. 25:1795-1803.
2006